Nuclear Medicine


Nuclear medicine is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of some of the most aggressive types of cancer.  Targeted alpha therapy focused on the use of powerful and localized alpha-emitting isotopes is part of nuclear medicine that has proven to be particularly promising.

"We believe Orano Med can make a difference in the fight against cancer.  By combining the latest advances in medical and nuclear science, we are developing innovative targeted alpha therapy treatments to combat the disease."

Julien Dodet, President and CEO of Orano Med

  • Targeted Alpha Therapy

    Orano Med's Innovative Approach in the Fight Against Cancer

    Targeted alpha therapy (TAT) works by combining the targeting capabilities of cancer cell-specific biological carriers (e.g., antibodies) with the short-range destroying capabilities of the radioactive isotope 212Pb.  This approach targets and destroys cancer cells while limiting the impact on nearby healthy cells.

  • What is Lead-212?

    Lead-212 (212Pb), a rare radioactive isotope that is part of the thorium-232 decay chain, is currently at the heart of promising research projects in nuclear medicine to develop new treatments against cancer.  This innovative approach is known as targeted alpha therapy (TAT).   Orano Med has developed new processes to extract and purify 212Pb from a vast supply of thorium resulting from Orano's mining activities in the 1950s-1970s.  The short half-life of 212Pb makes it ideally suited for patient administration.

    Thorium-232 Decay Chain

  • Research

    Orano Med Creates New Research Opportunities for Targeted Alpha Therapy (TAT)


    A high potential for TAT was established years ago, but scarcity of isotopes was an obstacle to progress.

    Early preclinical studies and clinical trials from the 1980s with targeted alpha therapy showed potential for treating different types of cancer that do not respond to other conventional methods, despite the significant efforts made by the global scientific and medical communities.

    Though the effectiveness of 212Pb had been demonstrated, the development of TAT treatments using this isotope encountered setbacks early on due to its scarcity and the technical difficulties of producing high-purity 212Pb.

    Technical and scientific breakthroughs make high-purity 212Pb more widely available to explore further TAT potential.

    Orano Med's research and development work has made it possible to produce high-purity 212Pb to develop new cancer treatments and increase production capacity.  The Orano Med team, in collaboration with leading scientists, chemists, and radiochemists, has developed innovative methods for radiolabeling biological carriers with a radioactive isotope.  As a result, targeted alpha therapy using 212Pb has recently come back to the forefront of medical research.

  • Production

    Orano Med's 212Pb Production Facilities:  Scaling up Production in France and in the U.S. 

    Laboratoire Maurice Tubiana (LMT)

    Laboratoire Maurice Tubiana (LMT)

    Orano Med has built a unique facility to produce high-purity 212Pb needed for clinical development.  This facility is located in Bessines-sur-Gartempe in the Limousin region of France. In 2013, this one-of-a-kind facility, named after world-renowned oncologist Professor Maurice Tubiana*, became fully operational and began producing 212Pb generators.  Orano Med is continuously investing to improve the production process and capacity. 

    Domestic Distribution and Purification Unit (DDPU)

                       DDPU Photo Credit:  Jim Herndon, On Location Portraiture

    Following the completion of the LMT in France in 2013, this new facility, located in Plano, Texas, was inaugurated in 2016.  The DDPU increases Orano Med's 212Pb production capacity, and its modular design allows for expansion to accommodate future clinical and commercial development. 

    With production facilities operational in both the U.S. and France, Orano Med is now positioned to serve the needs of the medical community even better, both domestically and abroad.  At the same time, the DDPU supports the development of Orano Med's pipeline focused on innovative, targeted, and powerful 212Pb treatments to fight cancer.

    Future Large-Scale Production Facility in France

    Conceptual rendering of the future production Facility

    A future facility, currently in the planning stages, will dramatically increase the production capacity of the LMT in France and the DDPU in the U.S., to serve future commercial medical needs.  Construction of this facility will begin as our scientific programs achieve certain milestones.


    Orano Med:  Developing Nuclear Medicine for Tomorrow’s Cancer Treatments

    Orano Med is a nuclear biotech company developing innovative therapies in oncology. OranoMed has developed new processes for producing lead-212 (212Pb), a rare radioactive isotope used in Targeted Alpha Therapy (TAT), an innovative and promising approach of nuclear medicine allowing to recognize and destroy cancer cells while limiting the impact on nearby healthy cells. With its partners, Orano Med pursues the development of effective therapies to address cancer patients’ needs. Orano Med is the medical subsidiary of the Orano group.

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For more information about Orano Med, please contact:
Alison Tise
Tel.: + 1 (301) 841-1673